Emma Wedgwood

Profhilo vs Polynucleotides - Which Should You Choose?

Sept. 30, 2023

Looking to achieve radiance and glow to your skin without anything too invasive treatment wise? Enter the latest skin booster contenders in the world of aesthetics: Profhilo and Polynucleotides. But which one should you choose? In this ultimate showdown, we'll pit these two popular treatments against each other to help you make an informed decision.

Profhilo, well known as the "moisture-boosting injectable," uses revolutionary technology to enhance skin hydration and overall quality. With its unique combination of high and low molecular weight hyaluronic acid, Profhilo promises to stimulate collagen production and improve skin elasticity. On the other hand, Polynucleotides, often referred to as "PDRN therapy," harnesses the power of DNA fragments to regenerate tired and damaged skin at a cellular level. This cutting-edge treatment claims to accelerate tissue repair, reduce wrinkles, and promote a brighter complexion. 

We will compare the benefits, efficacy, and side effects of Profhilo and Polynucleotides, providing you with all the information you need to make an educated choice. Whether you're looking to reduce fine lines or enhance skin hydration, get ready to discover the perfect treatment for your skincare goals. 

Both Profhilo and Polynucleotides offer remarkable benefits, but they differ in their approach and mechanism of action. Profhilo focuses on boosting moisture levels and promoting collagen production, while Polynucleotides work by repairing damaged skin cells through the use of DNA fragments. Understanding these differences is essential in determining which treatment aligns better with your skincare goals. 

The benefits of Profhilo 

Profhilo offers a range of benefits that make it a sought-after treatment for those looking to achieve a more, plump and dewy complexion. First and foremost, Profhilo's unique formulation of hyaluronic acid provides intense hydration to the skin, resulting in improved skin quality and luminosity. Additionally, Profhilo's ability to stimulate collagen production helps to address common signs of aging, such as fine lines and wrinkles. By promoting the production of collagen, Profhilo can restore skin elasticity and firmness, leading to a more youthful and rejuvenated appearance. Another notable benefit of Profhilo is its compatibility with other aesthetic treatments. Whether you're considering dermal fillers or Botox, Profhilo can be used in combination with these treatments to further enhance their results. This versatility makes Profhilo a popular choice among individuals seeking a combination approach to their skincare repertoire.

The benefits of Polynucleotides 

Polynucleotides, or PDRN therapy, offer a unique set of benefits that make it an appealing option for those looking to revitalise their skin. One of the key advantages of Polynucleotides is its ability to accelerate tissue repair. By harnessing the power of DNA fragments, Polynucleotides promote cellular regeneration, which basically slows the ageing process at a cellular level.In addition to tissue repair, Polynucleotides are also known for their anti-inflammatory properties helping reduce redness and pigmentation. This treatment can also effectively reduce the appearance of fine lines and wrinkles, resulting in a smoother and more youthful complexion. Furthermore, Polynucleotides have been shown to improve skin texture and tone, making it an excellent choice for individuals with uneven skin surface. 

Comparing the effectiveness of Profhilo and Polynucleotides 

When it comes to comparing the effectiveness of Profhilo and Polynucleotides, it's important to consider individual goals and skin conditions. Both treatments have shown impressive results in their respective areas of focus, but their effectiveness can vary depending on the specific needs of each individual. Profhilo excels in providing intense hydration and stimulating collagen production, making it an excellent choice for individuals with dry or dehydrated skin. This treatment is also effective in improving overall skin quality and firmness, making it suitable for those looking to address signs of ageing such as fine lines and wrinkles. On the other hand, Polynucleotides are particularly beneficial for individuals with damaged or tired skin. This treatment's ability to accelerate tissue repair can greatly improve the appearance of scars, wrinkles, and uneven skin texture. Polynucleotides are also known for their ability to promote a brighter complexion, making it a popular choice for individuals seeking a more radiant and youthful appearance. 
Ultimately, the effectiveness of Profhilo and Polynucleotides will depend on individual factors such as skin type, age, and specific concerns. Consulting with a qualified medical aesthetic practitioner is crucial in determining which treatment is best suited for your unique needs.

Factors to consider when choosing between Profhilo and Polynucleotides 


When deciding between Profhilo and Polynucleotides, there are several factors to consider. Firstly, it's important to assess your skincare goals and determine which treatment aligns best with your desired outcomes. If you're primarily concerned with hydration and collagen stimulation, Profhilo may be the ideal choice. However, if you're looking to repair damaged skin and improve overall skin texture, Polynucleotides may be more suitable. 


Additionally, cost and availability are important factors to consider. The price of Profhilo and Polynucleotides can vary depending on location and clinic reputation. It is always best to do some research and check the credentials of a practitioner or clinic before parting with your cash. Treatment sessions and delivery schedule can differ slightly so worth discussing with your practitioner exactly how many treatments will be required to achieve desired results. 

Factoring in downtime with Profhilo tend to be reasonably straightforward as most people will experience a few bumps that no-one else notices that usually dissipate over the next few hours following treatment and gone by the next day, whereas PN’s immediately look like a sworm of bees have attacked and this initial swelling can last for 2 or 3 days post treatment.

Client testimonials and experiences with Profhilo and Polynucleotides 

To gain further insight into the experiences of individuals who have undergone Profhilo and Polynucleotides treatments, it's helpful to explore client testimonials. Hearing firsthand accounts can provide valuable information about the effectiveness, side effects, and overall satisfaction with the treatments. Many individuals who have tried Profhilo have reported significant improvements in skin hydration, firmness, and overall quality. Clients often praise the natural-looking results and the long-lasting effects of the treatment. The non-invasive nature of Profhilo is also a frequently mentioned advantage, as it allows for minimal downtime and a quick recovery process. Similarly, clients who have undergone Polynucleotides treatments have reported positive outcomes, particularly in terms of laxity and wrinkle reduction. Many individuals have expressed satisfaction with the noticeable improvement in their skin texture and tone. The convenience of fewer treatment sessions and longer-lasting results is often highlighted as a significant benefit of Polynucleotides. While client testimonials can provide valuable insights, it's important to remember that individual experiences may vary. What works for one person may not necessarily work for another. Consulting with a qualified aesthetic practitioner is essential in determining the most suitable treatment for your specific needs and goals. 

The cost and availability of Profhilo and Polynucleotides 

The cost of Profhilo and Polynucleotides treatments can vary depending on several factors, including the location, clinic reputation, and the number of treatment sessions required. Generally, Profhilo is priced per treatment area, with costs ranging from $500 to $1500 per session. Polynucleotides treatments, on the other hand, can range from $800 to $2000 per session, depending on the extent of the treatment and the desired outcomes. It's important to note that these prices are approximate and can vary significantly depending on the clinic and region. It's advisable to research multiple clinics and compare prices to ensure you're getting the best value for your investment. Additionally, some clinics offer package deals or discounts for multiple sessions, so it's worth inquiring about any available promotions. Availability of Profhilo and Polynucleotides treatments may also vary depending on the region. While both treatments have gained popularity in recent years, they may not be widely available in all areas. It's recommended to check with local aesthetic clinics or dermatologists to determine if these treatments are offered in your vicinity. 

Consultation and treatment process for Profhilo and Polynucleotides 

Before undergoing either Profhilo or Polynucleotides treatments, a consultation with a qualified aesthetic practitioner is essential. During this consultation, the practitioner will assess your skin condition, discuss your skincare goals, and determine which treatment is most suitable for you. The treatment process for Profhilo typically involves five injections into the face or specific areas of the body. The number of injections and the treatment areas will vary depending on individual needs. The procedure itself is relatively quick, usually taking around 30 minutes and is generally well-tolerated. Polynucleotides treatment typically follows a similar process, with a series of injections administered into the desired treatment areas. The number of injections and the treatment areas will be determined during the consultation, usually a larger number of injections compared to Profhilo. The procedure duration is similar to that of Profhilo, with minimal to moderate discomfort reported by most individuals. Anaesthetic cream can be applied before both treatments. 
After the treatment, it's important to follow any post-treatment instructions provided by the practitioner. This may include avoiding strenuous exercise, sun exposure, or certain skincare products for 24 hours. Adhering to post procedure guidelines will always help optimise the results and minimise any potential side effects. 

Conclusion: Making an informed decision between Profhilo and Polynucleotides 

Choosing between Profhilo and Polynucleotides can be an overwhelming task, considering both treatments offer significant benefits for individuals seeking a more youthful and radiant appearance.Profhilo excels in providing intense hydration, stimulating collagen production, and improving overall skin quality. It is an excellent choice for individuals looking to address dryness, fine lines, and wrinkles. On the other hand, Polynucleotides offer accelerated tissue repair, wrinkle reduction, and improved skin texture. It is particularly beneficial for individuals with damaged, ageing or tired skin.
 Factors such as individual goals, skin condition, potential side effects, and cost should be considered when choosing between Profhilo and Polynucleotides. Consulting with a professional will provide guidance and ensure you receive the most suitable treatment for your unique needs. Remember, each person's experience with these treatments may vary, so it's essential to set realistic expectations and be patient with the results. With the right treatment and proper skincare routine, you can achieve your best skin condition. And of Course, there is absolutely nothing preventing you from having both treatments if you wanted as they would very much compliment one another.

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